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TP73 tetramer translocates to the nucleus
Stable Identifier
R-HSA-8957241
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
TP73 tetramer translocates to the nucleus (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TP73 (p73) possesses both a nuclear localization signal (NLS) and a nuclear export signal (NES) and can shuttle between the nucleus and the cytosol (Inoue et al. 2002).
Literature References
PubMed ID
Title
Journal
Year
11847229
Nuclear import and export signals in control of the p53-related protein p73
Leno, R
,
Inoue, T
,
Maki, CG
,
Stuart, J
J. Biol. Chem.
2002
Participants
Input
TP73 Tetramer [cytosol]
(Homo sapiens)
Output
TP73 Tetramer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
RUNX1 regulates transcription of genes involved in differentiation of HSCs (Homo sapiens)
Orthologous Events
TP73 tetramer translocates to the nucleus (Bos taurus)
TP73 tetramer translocates to the nucleus (Danio rerio)
TP73 tetramer translocates to the nucleus (Drosophila melanogaster)
TP73 tetramer translocates to the nucleus (Gallus gallus)
TP73 tetramer translocates to the nucleus (Mus musculus)
TP73 tetramer translocates to the nucleus (Rattus norvegicus)
TP73 tetramer translocates to the nucleus (Sus scrofa)
TP73 tetramer translocates to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2016-09-14)
Reviewed
Chuang, LS (2016-12-20)
Ito, Y (2016-12-20)
Created
Orlic-Milacic, M (2017-01-24)
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