MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex

Stable Identifier
R-HSA-8956608
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MYB gene transcription is stimulated by the RUNX1-containing TAL1 complex
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Expression of the MYB gene is stimulated by binding of the RUNX1-containing TAL1 complex to the MYB gene enhancer (Sanda et al. 2012, Mansour et al. 2014). MYB transcription factor encoded by the MYB gene can bind to the RUNX1-containing TAL1 complex at the MYB gene enhancer to further facilitate MYB gene expression, thus creating a positive feedback loop (Mansour et al. 2014). In addition, somatic mutations at the TAL1 gene enhancer enable binding of the TAL1 complex containing MYB, RUNX1 and MYB-associated histone acetyltransferase CBP (CREBBP) to the TAL1 gene enhancer, creating a super-enhancer, which further amplifies the positive feedback loop involved in the MYB gene regulation (Mansour et al. 2014).
Literature References
PubMed ID Title Journal Year
25394790 Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Sallan, SE, Hunger, SP, Mansour, MR, Lawton, L, Berezovskaya, A, Etchin, J, Anders, L, Sanda, T, Durbin, AD, Look, AT, Young, RA, Silverman, LB, Abraham, BJ, Gutierrez, A, Loh, ML

Science 2014
22897851 Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia

Kelliher, MA, Ma, W, Barrasa, MI, Tatarek, J, Sanda, T, Look, AT, Fan, ZP, Young, RA, Jamieson, CH, Lawton, LN, Ahn, Y, Gutierrez, A, Kohlhammer, H, Staudt, LM

Cancer Cell 2012
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
RUNX1:CBFB:GATA3-TAL1 core complex:MYB gene [nucleoplasm] (Homo sapiens)
Active Unit
RUNX1:CBFB:GATA3-TAL1 core complex,MYB:RUNX1:CBFB:GATA3-TAL1 core complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2017-01-24)
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