E2F6 binds the PRC1 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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E2F6, presumably in complex with TFDP1 (DP-1) or TFDP2 (DP-2), interacts with components of the Polycomb group (PcG) complex PRC1: BMI1, RYBP, RING1 (RING1A), PCGF2 (MEL-18) and PHC1 (mPH1) (Trimarchi et al. 2001), as well as PHC3 (Deshpande et al. 2007). The PRC1 complex may contribute to E2F6-mediated transcriptional repression. PHC3 exhibits frequent loss of heterozygosity (LoH) in primary human osteosarcoma tumors (Deshpande et al. 2007).

Literature References
PubMed ID Title Journal Year
11171983 The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

Trimarchi, JM, Fairchild, B, Wen, J, Lees, JA

Proc. Natl. Acad. Sci. U.S.A. 2001
17001316 PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors

Deshpande, AM, Akunowicz, JD, Reveles, XT, Patel, BB, Saria, EA, Gorlick, RG, Naylor, SL, Leach, RJ, Hansen, MF

Oncogene 2007
Participant Of
Orthologous Events
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