E2F6 binds the PRC1 complex

Stable Identifier
R-HSA-8954082
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

E2F6, presumably in complex with TFDP1 (DP-1) or TFDP2 (DP-2), interacts with components of the Polycomb group (PcG) complex PRC1: BMI1, RYBP, RING1 (RING1A), PCGF2 (MEL-18) and PHC1 (mPH1) (Trimarchi et al. 2001), as well as PHC3 (Deshpande et al. 2007). The PRC1 complex may contribute to E2F6-mediated transcriptional repression. PHC3 exhibits frequent loss of heterozygosity (LoH) in primary human osteosarcoma tumors (Deshpande et al. 2007).

Literature References
PubMed ID Title Journal Year
11171983 The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex

Trimarchi, JM, Fairchild, B, Wen, J, Lees, JA

Proc. Natl. Acad. Sci. U.S.A. 2001
17001316 PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors

Deshpande, AM, Akunowicz, JD, Reveles, XT, Patel, BB, Saria, EA, Gorlick, RG, Naylor, SL, Leach, RJ, Hansen, MF

Oncogene 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created
Cite Us!