JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4

Stable Identifier
R-HSA-8950453
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Interleukin-35 (IL35) binding activates the IL35 receptor complex and facilitates Tyrosine-protein kinase JAK (JAK) phosphorylation. Subsequently, Signal transducer and activator of transcription 1-alpha/beta (STAT1) and STAT4 bind to the receptor complex and are activated by tyrosine phosphorylation (Collison et al. 2012). Although it is known that JAKs are involved in STATs phosphorylation (Stark GR and Darnell JE, 2012), it is not clear how other components of the IL35 receptor complex contribute to STAT1/STAT4 phosphorylation. For this reason, this event is assigned a black box status.

Literature References
PubMed ID Title Journal Year
24058793 STAT heterodimers in immunity: A mixed message or a unique signal?

Delgoffe, GM, Vignali, DA

JAKSTAT 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of IL35:IL6ST:p-JAK1:IL12RB2:p-JAK2:STAT1:STAT4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created
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