SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)

Stable Identifier
R-HSA-8949703
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)
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As inferred from rat Slc8a3 and mouse Akap1 (Akap121), SLC8A3 in a complex with AKAP1 exchanges cytosolic sodium ions for divalent calcium from the mitochondrial intermembrane space resulting in an efflux of calcium from the mitochondrion. The mitochondrial localization of SLC8A3 is controversial, however, and SLC8A3 has a limited tissue distribution.
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Output
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Catalyst Activity

calcium:sodium antiporter activity of SLC8A3:AKAP1 [mitochondrial outer membrane]

Physical Entity
SLC8A3:AKAP1 [mitochondrial outer membrane] (Homo sapiens)
Activity
calcium:sodium antiporter activity (GO:0005432)
Inferred From
Slc8a3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) (Mus musculus)
Cross References
Rhea
Authored
May, B  (2016-11-28)
Reviewed
Drago, I  (2017-01-21)
Created
May, B  (2016-11-28)
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