Reactome | MKRN1 polyubiquitinates PTEN

MKRN1 polyubiquitinates PTEN

Stable Identifier

R-HSA-8948775

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The C-terminal region of the E3 ubiquitin ligase MKRN1 interacts with PTEN and polyubiquitinates it on lysine residue K289, via K48 linkage. AKT-mediated phosphorylation of MKRN1 on serine residue S109 is a pre-requisite for MKRN1 stabilization and MKRN1-mediated ubiquitination of PTEN. MKRN1 is implicated as an oncogene in cervical cancer (Lee et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
26183061	PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis Lee, MS, Jeong, MH, Lee, HW, Han, HJ, Ko, A, Hewitt, SM, Kim, JH, Chun, KH, Chung, JY, Lee, C, Cho, H, Song, J	Nat Commun	2015