MKRN1 polyubiquitinates PTEN

Stable Identifier
R-HSA-8948775
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The C-terminal region of the E3 ubiquitin ligase MKRN1 interacts with PTEN and polyubiquitinates it on lysine residue K289, via K48 linkage. AKT-mediated phosphorylation of MKRN1 on serine residue S109 is a pre-requisite for MKRN1 stabilization and MKRN1-mediated ubiquitination of PTEN. MKRN1 is implicated as an oncogene in cervical cancer (Lee et al. 2015).

Literature References
PubMed ID Title Journal Year
26183061 PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

Lee, MS, Jeong, MH, Lee, HW, Han, HJ, Ko, A, Hewitt, SM, Kim, JH, Chun, KH, Chung, JY, Lee, C, Cho, H, Song, J

Nat Commun 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p-S109-MKRN1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Created