The C-terminal region of the E3 ubiquitin ligase MKRN1 interacts with PTEN and polyubiquitinates it on lysine residue K289, via K48 linkage. AKT-mediated phosphorylation of MKRN1 on serine residue S109 is a pre-requisite for MKRN1 stabilization and MKRN1-mediated ubiquitination of PTEN. MKRN1 is implicated as an oncogene in cervical cancer (Lee et al. 2015).
Hewitt, SM, Han, HJ, Lee, MS, Lee, C, Chung, JY, Kim, JH, Jeong, MH, Ko, A, Cho, H, Lee, HW, Song, J, Chun, KH
ubiquitin protein ligase activity of p-S109-MKRN1 [cytosol]
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