Collagen chain trimerization

Stable Identifier
Homo sapiens
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The C-propeptides of collagen propeptide chains are essential for the association of three peptide chains into a trimeric but non-helical procollagen. This initial binding event determines the composition of the trimer, brings the individual chains into the correct register and initiates formation of the triple helix at the C-terminus, which then proceeds towards the N-terminus in a zipper-like fashion (Engel & Prockop 1991). Most early refolding studies were performed with collagen type III, which contains a disulfide linkage at the C-terminus of its triple helix (Bächinger et al. 1978, Bruckner et al. 1978) that acts as a permanent linker even after removal of the non-collagenous domains.

Mutations within the C-propeptides further suggest that they are crucial for the correct interaction of the three polypeptide chains and for subsequent correct folding (refs. in Boudko et al. 2011).

Literature References
PubMed ID Title Journal Year
710450 The role of cis-trans isomerization of peptide bonds in the coil leads to and comes from triple helix conversion of collagen

Timpl, R, Brückner, P, Engel, J, Bächinger, HP

Eur J Biochem 1978
171650 Interchain disulfide bonds in procollagen are located in a large nontriple-helical COOH-terminal domain

Byers, PH, Bornstein, P, Click, EM, Harper, E

Proc Natl Acad Sci U S A 1975
Event Information
Orthologous Events
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