miR-20 microRNAs bind PTEN mRNA

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R-HSA-8945709
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Reaction [binding]
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Homo sapiens
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MicroRNAs miR-20a-5p and miR-20b-5p, encoded by MIR20A and MIR20B genes, respectively, bind the 3'UTR of PTEN mRNA and downregulate PTEN mRNA translation (Poliseno et al. 2010, Tay et al. 2011). miR-20a-5p downregulates both PTEN mRNA and protein levels and is thus considered to function as part of the endonucleolytic RISC, but it may also function as a part of nonendonucleolytic RISC (Poliseno et al. 2010). miR-20b presumably functions in a similar manner (Tay et al. 2011).

Literature References
PubMed ID Title Journal Year
20577206 A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

Poliseno, L, Salmena, L, Zhang, J, Carver, B, Haveman, WJ, Pandolfi, PP

Nature 2010
22000013 Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs

Tay, Y, Kats, L, Salmena, L, Weiss, D, Tan, SM, Ala, U, Karreth, F, Poliseno, L, Provero, P, Di Cunto, F, Lieberman, J, Rigoutsos, I, Pandolfi, PP

Cell 2011
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