miR-21 nonendonucleolytic RISC binds PTEN mRNA

Stable Identifier
R-HSA-8944706
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
miR-21 nonendonucleolytic RISC binds PTEN mRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

miR-21-5p, one of the two mature products of miR-21, binds the 3'UTR of PTEN mRNA to inhibit PTEN mRNA translation. miR-21 only affects PTEN protein level and thus presumably functions as part of the nonendonucleolytic RISC (Meng et al. 2007, Zhang et al. 2010)

Literature References
PubMed ID Title Journal Year
20223231 MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Yang, GH, Liu, Q, Wang, JJ, Zhang, JG, Jiang, K, Zhao, F

Clin. Chim. Acta 2010
17681183 MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

Wehbe-Janek, H, Patel, T, Meng, F, Henson, R, Jacob, ST, Ghoshal, K

Gastroenterology 2007
Participants
Input
Output
Participates
as an event of
Authored
Salmena, L  (2016-08-11)
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-04)
Cite Us!