miR-21 nonendonucleolytic RISC binds PTEN mRNA

Stable Identifier
R-HSA-8944706
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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miR-21 nonendonucleolytic RISC binds PTEN mRNA
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miR-21-5p, one of the two mature products of miR-21, binds the 3'UTR of PTEN mRNA to inhibit PTEN mRNA translation. miR-21 only affects PTEN protein level and thus presumably functions as part of the nonendonucleolytic RISC (Meng et al. 2007, Zhang et al. 2010)
Literature References
PubMed ID Title Journal Year
20223231 MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)

Zhang, JG, Wang, JJ, Zhao, F, Liu, Q, Jiang, K, Yang, GH

Clin. Chim. Acta 2010
17681183 MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

Meng, F, Henson, R, Wehbe-Janek, H, Ghoshal, K, Jacob, ST, Patel, T

Gastroenterology 2007
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Authored
Orlic-Milacic, M  (2016-11-03)
Carracedo, A  (2016-08-11)
Salmena, L  (2016-08-11)
Reviewed
Leslie, N  (2016-09-30)
Kriplani, N  (2016-09-30)
Created
Orlic-Milacic, M  (2016-11-04)
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