miR-214 microRNA binds PTEN mRNA

Stable Identifier
R-HSA-8944650
Type
Reaction
Species
Homo sapiens
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Summation

MicroRNA miR-214-3p, one of the two mature products of miR-214, binds to the 3'UTR of the PTEN mRNA and inhibits PTEN mRNA translation. As miR-214 reduces PTEN protein levels but not PTEN mRNA levels, miR-214 presumably functions as part of the nonendonucleolytic RISC. miR-214 is frequently overexpressed in ovarian cancer (Yang et al. 2008).

Literature References
PubMed ID Title Journal Year
18199536 MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN

Yang, H, Kong, W, He, L, Zhao, JJ, O'Donnell, JD, Wang, J, Wenham, RM, Coppola, D, Kruk, PA, Nicosia, SV, Cheng, JQ

Cancer Res. 2008
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