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miR-19b Nonendonucleolytic RISC [cytosol]
Stable Identifier
R-HSA-8944508
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN mRNA translation (Homo sapiens)
Competing endogenous RNAs (ceRNAs) regulate PTEN translation (Homo sapiens)
PTENP1 mRNA binds miR-19b RISC (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:PTENP1 mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b microRNA binds CNOT6L mRNA (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:CNOT6L mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
PTEN mRNA translation is negatively regulated by microRNAs (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:PTEN mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b microRNA binds PTEN mRNA (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:CNOT6L mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:PTEN mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
miR-19b RISC:PTENP1 mRNA [cytosol] (Homo sapiens)
miR-19b RISC [cytosol] (Homo sapiens)
miR-19b Nonendonucleolytic RISC [cytosol] (Homo sapiens)
General
The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage. In vivo, cleavage by AGO2 and repression of translation by all AGOs require interaction with a TNRC6 protein (GW182 protein) and MOV10. The interaction with TNRC6 proteins is also responsible for localizing the AGO complex to Processing Bodies (P-bodies). Tethering of the C-terminal domain of a TNRC6 protein to a mRNA is sufficient to cause repression of translation.
Participants
components
miR-19b Nonendonucleolytic Minimal RISC [cytosol]
(Homo sapiens)
MOV10 [cytosol]
(Homo sapiens)
TNRC6 (GW182) [cytosol]
(Homo sapiens)
Participates
as a candidate of
miR-19b RISC [cytosol] (Homo sapiens)
Inferred To
miR-19b Nonendonucleolytic RISC [cytosol]
(Bos taurus)
miR-19b Nonendonucleolytic RISC [cytosol]
(Canis familiaris)
miR-19b Nonendonucleolytic RISC [cytosol]
(Drosophila melanogaster)
miR-19b Nonendonucleolytic RISC [cytosol]
(Mus musculus)
miR-19b Nonendonucleolytic RISC [cytosol]
(Rattus norvegicus)
miR-19b Nonendonucleolytic RISC [cytosol]
(Sus scrofa)
miR-19b Nonendonucleolytic RISC [cytosol]
(Xenopus tropicalis)
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