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Filaggrin binds Keratin tonofilament:Desmosome
Stable Identifier
R-HSA-8942224
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
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During cornification, a network of keratin intermediate filaments (KIF) and filaggrin (FLG) becomes crosslinked to the cornified envelope (CE). The FLG-KIF linkage occurs primarily through a specific lysine residue on the head domain of type II keratin chains, which can crosslink with several CE proteins including loricrin, SPRs, envoplakin and involucrin (Dale et al. 1978, Manabe et al. 1991, Mack et al. 1993, Steinert et al. 1995, Candi et al. 1998). This FLG-KIF crosslinking is believed to organise intermediate filaments into bundles, which stabilize the keratin network (Steinert et al. 1981, Candi et al. 2005) and facilitate the collapse and flattening of cells in the outermost stratum corneum to produce squames. Cell flattening can occur in the absence of FLG, but at the ultrastructural level loss-of-function mutations in FLG are associated with disorganized keratin filaments, impaired lamellar body loading and abnormal architecture of the lamellar bilayer (Gruber et al. 2011).
Literature References
PubMed ID
Title
Journal
Year
7543090
The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope
Steinert, PM
,
Marekov, LN
J. Biol. Chem.
1995
Participants
Input
FLG(?-?) [cytosol]
(Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane]
(Homo sapiens)
Output
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane]
(Homo sapiens)
Participates
as an event of
Formation of the cornified envelope (Homo sapiens)
Orthologous Events
Filaggrin binds Keratin tonofilament:Desmosome (Canis familiaris)
Authored
Jupe, S (2016-09-23)
Reviewed
Blumenberg, M (2016-08-12)
Created
Jupe, S (2016-10-11)
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