CCND3,(CCND1,CCND2) binds RUNX1

Stable Identifier
R-HSA-8938867
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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CCND3,(CCND1,CCND2) binds RUNX1
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Cyclin D3 (CCND3) binds to the runt domain and the activation domain (AD) of RUNX1, thus inhibiting RUNX1 association with CBFB and RUNX1 binding to DNA. Based on in vitro studies, cyclins D1 (CCND1) and D2 (CCND2) can also bind to RUNX1 (Peterson et al. 2005).
Literature References
PubMed ID Title Journal Year
16287839 The hematopoietic transcription factor AML1 (RUNX1) is negatively regulated by the cell cycle protein cyclin D3

Boyapati, A, Peterson, LF, Iwama, A, Tsai, S, Ranganathan, V, Zhang, DE, Tenen, DG

Mol. Cell. Biol. 2005
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Orthologous Events
CCND3,(CCND1,CCND2) binds RUNX1 (Bos taurus)
CCND3,(CCND1,CCND2) binds RUNX1 (Caenorhabditis elegans)
CCND3,(CCND1,CCND2) binds RUNX1 (Canis familiaris)
CCND3,(CCND1,CCND2) binds RUNX1 (Danio rerio)
CCND3,(CCND1,CCND2) binds RUNX1 (Drosophila melanogaster)
CCND3,(CCND1,CCND2) binds RUNX1 (Gallus gallus)
CCND3,(CCND1,CCND2) binds RUNX1 (Mus musculus)
CCND3,(CCND1,CCND2) binds RUNX1 (Rattus norvegicus)
CCND3,(CCND1,CCND2) binds RUNX1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-12)
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