Reactome | RNF144A polyubiquitinates PRKDC

RNF144A polyubiquitinates PRKDC

Stable Identifier

R-HSA-8938773

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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The ubiquitin E3 ligase RNF144A transfers ubiquitin from the E2-ubiquitin conjugate UBE2L3:Ubiquitin to an unknown residue of PRKDC (DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase) (Ho et al. 2014). RNF144A polyubiquitinates PRKDC with lysine-48 linked ubiquitin, leading to proteasomal degradation of PRKDC. Expression of RNF144A is activated by TP53 (p53) and the degradation of PRKDC caused by RNF144A may be pro-apoptotic (Ho et al. 2014). RNF144A contains a transmembrane domain that localizes RNF144A to endosomal membranes (Ho et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
24979766	RNF144A, an E3 ubiquitin ligase for DNA-PKcs, promotes apoptosis during DNA damage Lin, WC, Mahanic, CS, Ho, SR, Lee, YJ	Proc. Natl. Acad. Sci. U.S.A.	2014
26216882	Regulation of RNF144A E3 Ubiquitin Ligase Activity by Self-association through Its Transmembrane Domain Lin, WC, Ho, SR, Lee, YJ	J. Biol. Chem.	2015