RUNX2 binds tyrosine phosphorylated YAP1

Stable Identifier
R-HSA-8937864
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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RUNX2 binds tyrosine phosphorylated YAP1
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Based on studies in rat, RUNX2, presumably associated with CBFB, binds YAP1, phosphorylated on an unknown tyrosine residue by SRC and/or YES1. The interaction involves the PY motif of RUNX2 (Zaidi et al. 2004).

Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
Participants
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Output
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as an event of
Inferred From
Runx2 binds p-Y-Yap1 (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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