PTPN11 binds p-7Y-RUNX1

Stable Identifier
R-HSA-8937744
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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PTPN11 binds p-7Y-RUNX1
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Based on mouse studies, tyrosine phosphorylated RUNX1 forms a complex with PTPN11 (SHP2) protein tyrosine phosphatase in the nucleus (Huang et al. 2012).
Literature References
PubMed ID Title Journal Year
22759635 A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation

Waldon, Z, Zhu, HH, Woo, AJ, Steen, H, Feng, GS, Schindler, Y, Cantor, AB, Huang, H, Moran, TB

Genes Dev. 2012
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Output
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Orthologous Events
PTPN11 binds p-7Y-RUNX1 (Bos taurus)
PTPN11 binds p-7Y-RUNX1 (Canis familiaris)
PTPN11 binds p-7Y-RUNX1 (Gallus gallus)
PTPN11 binds p-7Y-RUNX1 (Mus musculus)
PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)
PTPN11 binds p-7Y-RUNX1 (Sus scrofa)
PTPN11 binds p-7Y-RUNX1 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-09-06)
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