Reactome | AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

Stable Identifier

R-HSA-8937169

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

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After ligand binding and activation, the AHR complex translocates to the nucleus by an unknown mechanism (Beischlag et al. 2008) but it has been hypothesised that ligand binding to AHR promoted p23-associated hsp90 complex-mediated interaction of AHR with the nuclear import receptor protein pendulin and subsequent nuclear translocation of the receptor (Kazlauskas et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11259606	The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor Poellinger, L, Sundström, S, Pongratz, I, Kazlauskas, A	Mol. Cell. Biol.	2001
18540824	The aryl hydrocarbon receptor complex and the control of gene expression Perdew, GH, Hollingshead, BD, Luis Morales, J, Beischlag, TV	Crit. Rev. Eukaryot. Gene Expr.	2008