AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

Stable Identifier
R-HSA-8937169
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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After ligand binding and activation, the AHR complex translocates to the nucleus by an unknown mechanism (Beischlag et al. 2008) but it has been hypothesised that ligand binding to AHR promoted p23-associated hsp90 complex-mediated interaction of AHR with the nuclear import receptor protein pendulin and subsequent nuclear translocation of the receptor (Kazlauskas et al. 2001).

Literature References
PubMed ID Title Journal Year
18540824 The aryl hydrocarbon receptor complex and the control of gene expression

Beischlag, TV, Luis Morales, J, Hollingshead, BD, Perdew, GH

Crit. Rev. Eukaryot. Gene Expr. 2008
11259606 The hsp90 chaperone complex regulates intracellular localization of the dioxin receptor

Kazlauskas, A, Sundström, S, Poellinger, L, Pongratz, I

Mol. Cell. Biol. 2001
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