Reactome | AHR:2xHSP90:AIP:PTGES3 binds TCDD

AHR:2xHSP90:AIP:PTGES3 binds TCDD

Stable Identifier

R-HSA-8936849

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that can control the expression of a diverse set of genes. Two major types of environmental compounds can activate AHR signaling: halogenated aromatic hydrocarbons such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and polycyclic aromatic hydrocarbons (PAH) such as benzo(a)pyrene. Unliganded AHR forms a complex in the cytosol with two copies of 90kD heat shock protein (HSP90AB1) (Forsythe et al. 2001), one X-associated protein (AIP) (Meyer et al. 1998), and one p23 molecular chaperone protein (PTGES3) (Nguyen et al. 2012, Beischlag et al. 2008). Here, the binding of TCDD is shown.

Literature References

PubMed ID	Title	Journal	Year
18540824	The aryl hydrocarbon receptor complex and the control of gene expression Beischlag, TV, Luis Morales, J, Hollingshead, BD, Perdew, GH	Crit. Rev. Eukaryot. Gene Expr.	2008
12573486	Functional role of AhR in the expression of toxic effects by TCDD Mimura, J, Fujii-Kuriyama, Y	Biochim. Biophys. Acta	2003
11274138	Stable association of hsp90 and p23, but Not hsp70, with active human telomerase Forsythe, HL, Jarvis, JL, Turner, JW, Elmore, LW, Holt, SE	J Biol Chem	2001
22759865	p23 co-chaperone protects the aryl hydrocarbon receptor from degradation in mouse and human cell lines Nguyen, PM, Wang, D, Wang, Y, Li, Y, Uchizono, JA, Chan, WK	Biochem. Pharmacol.	2012
7961644	Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors Ema, M, Ohe, N, Suzuki, M, Mimura, J, Sogawa, K, Ikawa, S, Fujii-Kuriyama, Y	J. Biol. Chem.	1994
9447995	Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity Meyer, BK, Pray-Grant, MG, Vanden Heuvel, JP, Perdew, GH	Mol. Cell. Biol.	1998