H19 is cleaved to produce miR-675

Stable Identifier
R-HSA-8936068
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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H19 is cleaved to produce miR-675
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A long non-coding RNA (lncRNA) H19, frequently overexpressed in gastric cancer, functions as a precursor (pri-microRNA) in the production of microRNA miR-675 (Cai and Cullen 2007), which targets and downregulates RUNX1 mRNA, thus interfering with RUNX1 transcription (Zhuang et al. 2014).

Literature References
PubMed ID Title Journal Year
17237358 The imprinted H19 noncoding RNA is a primary microRNA precursor

Cai, X, Cullen, BR

RNA 2007
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Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Chuang, LS  (2016-12-20)
Ito, Y  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-16)
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