Mature single stranded microRNA miR-302b-3p, one of the two products of miR-302b encoded by the MIR302B gene, binds to the 3'UTR of RUNX1 mRNA, which results in decreased RUNX1 mRNA and protein levels. As it affects RUNX1 mRNA levels, miR-302b is assumed to function as a component of the endonucleolytic RISC, but it is possible that it additionally functions as a component of the nonendonucleolytic RISC. Levels of miR-302b are decreased in epithelial ovarian carcinoma (Ge et al. 2014).
Ge, T, Yin, M, Yang, M, Liu, T, Lou, G
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