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miR-302b Nonendonucleolytic Minimal RISC

Stable Identifier
R-HSA-8935853
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Synonyms
Argonaute1/3/4: miR-302b
Locations in the PathwayBrowser
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Summation

The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.

Participants
components
Participant Of
hasComponent
Inferred To
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Bos taurus)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Canis familiaris)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Danio rerio)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Gallus gallus)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Mus musculus)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Rattus norvegicus)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Sus scrofa)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Taeniopygia guttata)
miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Xenopus tropicalis)