miR-302b Nonendonucleolytic Minimal RISC

Summation

The RNA-induced silencing complex contains an Argonaute (AGO) protein, whose PAZ domain binds the 3' end of the miRNA. The PIWI domain of AGO is responsible for cleavage of target RNAs, that is, RNAs complementary to the miRNA. Only AGO2 (EIF2C2) is capable of cleavage, however. AGO1 (EIF2C1), AGO3 (EIF2C3), and AGO4 (EIF2C4) repress translation of target RNAs by binding without cleavage.

Participants

components

• miR-302b [cytosol] (Homo sapiens)
• Nonendonucleolytic Argonaute [cytosol] (Homo sapiens)

Participant Of

hasComponent

• miR-302b Nonendonucleolytic RISC [cytosol]

Inferred To

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Bos taurus)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Canis familiaris)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Danio rerio)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Gallus gallus)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Mus musculus)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Rattus norvegicus)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Sus scrofa)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Taeniopygia guttata)

miR-302b Nonendonucleolytic Minimal RISC [cytosol] (Xenopus tropicalis)