Several microRNAs inhibit RUNX1 mRNA translation without affecting RUNX1 mRNA levels and are thus assumed to function as components of the nonendonucleolytic RISC. These microRNAs include miR 17, miR 20a and miR 106a (Fontana et al. 2007), miR 27a (Ben-Ami et al. 2009), miR 378a (Browne et al. 2016). As RUNX1 directly regulates transcription of the MIR27A gene, RUNX1 and MIR27A constitute a negative feedback loop involved in megakaryocyte differentiation and may regulate the switch between megakaryocytic and erythroid lineages (Ben Ami et al. 2009).Inhibition of RUNX1 mRNA translation by other microRNAs results in decreased RUNX1 mRNA levels and these microRNAs are therefore assumed to function as components of the endonucleolytic RISC but it is possible that they additionally function as components of nonendonucleolytic RISC. MicroRNAs in this group include miR-18a (Miao et al. 2015), miR-215 (Li et al. 2016), miR-302b (Ge et al. 2014) and miR 675 (Zhuang et al. 2014). MicroRNA miR 215 binding to the 3'UTR of RUNX1 mRNA inhibits RUNX1 mRNA translation and reduces RUNX1 mRNA levels (Li et al. 2016).
Messier, TL, Browne, G, Lian, JB, Stein, JL, VanOudenhove, JJ, Farina, NH, Hong, D, Dragon, JA, Boyd, JR, Perez, AW, Gordon, JA, Stein, GS, Zaidi, SK
Xue, YX, Wang, P, Zhao, YY, Miao, YS, Ma, J, Liu, YH, Zhao, LN
Lou, G, Yang, M, Ge, T, Liu, T, Yin, M
Groner, Y, Pencovich, N, Lotem, J, Levanon, D, Ben-Ami, O
Xu, J, Gao, W, Wang, P, Zhuang, M, Shu, Y
Tian, TT, Ge, S, Zhang, QY, Shen, L, Li, ZW, Gao, J, Zhu, Y, Liu, XJ, Dong, B, Li, N, Zou, JL
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