RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675

Stable Identifier
R-HSA-8935785
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Several microRNAs inhibit RUNX1 mRNA translation without affecting RUNX1 mRNA levels and are thus assumed to function as components of the nonendonucleolytic RISC. These microRNAs include miR 17, miR 20a and miR 106a (Fontana et al. 2007), miR 27a (Ben-Ami et al. 2009), miR 378a (Browne et al. 2016). As RUNX1 directly regulates transcription of the MIR27A gene, RUNX1 and MIR27A constitute a negative feedback loop involved in megakaryocyte differentiation and may regulate the switch between megakaryocytic and erythroid lineages (Ben Ami et al. 2009).
Inhibition of RUNX1 mRNA translation by other microRNAs results in decreased RUNX1 mRNA levels and these microRNAs are therefore assumed to function as components of the endonucleolytic RISC but it is possible that they additionally function as components of nonendonucleolytic RISC. MicroRNAs in this group include miR-18a (Miao et al. 2015), miR-215 (Li et al. 2016), miR-302b (Ge et al. 2014) and miR 675 (Zhuang et al. 2014). MicroRNA miR 215 binding to the 3'UTR of RUNX1 mRNA inhibits RUNX1 mRNA translation and reduces RUNX1 mRNA levels (Li et al. 2016).
Literature References
PubMed ID Title Journal Year
26749280 MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells

Browne, G, Dragon, JA, Hong, D, Messier, TL, Gordon, JA, Farina, NH, Boyd, JR, VanOudenhove, JJ, Perez, AW, Zaidi, SK, Stein, JL, Stein, GS, Lian, JB

Tumour Biol. 2016
25452107 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5

Miao, YS, Zhao, YY, Zhao, LN, Wang, P, Liu, YH, Ma, J, Xue, YX

Cell. Signal. 2015
25562167 MicroRNA-302b suppresses human epithelial ovarian cancer cell growth by targeting RUNX1

Ge, T, Yin, M, Yang, M, Liu, T, Lou, G

Cell. Physiol. Biochem. 2014
19114653 A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis

Ben-Ami, O, Pencovich, N, Lotem, J, Levanon, D, Groner, Y

Proc. Natl. Acad. Sci. U.S.A. 2009
24388988 The long non-coding RNA H19-derived miR-675 modulates human gastric cancer cell proliferation by targeting tumor suppressor RUNX1

Zhuang, M, Gao, W, Xu, J, Wang, P, Shu, Y

Biochem. Biophys. Res. Commun. 2014
26716895 miR-215 promotes malignant progression of gastric cancer by targeting RUNX1

Li, N, Zhang, QY, Zou, JL, Li, ZW, Tian, TT, Dong, B, Liu, XJ, Ge, S, Zhu, Y, Gao, J, Shen, L

Oncotarget 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RUNX1 mRNA:miR-378 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Active Unit
miR-378 Nonendonucleolytic RISC [cytosol]
Regulator
RUNX1 mRNA:miR-17 Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Active Unit
miR-17 Nonendonucleolytic RISC [cytosol]
Regulator
RUNX1 mRNA:miR-675 RISC [cytosol] (Homo sapiens)
Active Unit
miR-675 RISC [cytosol]
Regulator
RUNX1 mRNA:miR-20a Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Active Unit
miR-20a Nonendonucleolytic RISC [cytosol]
Regulator
RUNX1 mRNA:miR-302b RISC [cytosol] (Homo sapiens)
Active Unit
miR-302b RISC [cytosol]
Regulator
RUNX1 mRNA:miR-106a Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Active Unit
miR-106a Nonendonucleolytic RISC [cytosol]
Regulator
RUNX1 mRNA:miR-18a RISC [cytosol] (Homo sapiens)
Active Unit
miR-18a RISC [cytosol]
Regulator
RUNX1 mRNA:miR-27a Nonendonucleolytic RISC [cytosol] (Homo sapiens)
Active Unit
miR-27a Nonendonucleolytic RISC [cytosol]
Regulator
RUNX1 mRNA:miR-215 RISC [cytosol] (Homo sapiens)
Active Unit
miR-215 RISC [cytosol]
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-08-15)
Cite Us!