Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
ITGA2B gene
Stable Identifier
R-HSA-8935722
Type
DNA Sequence [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm] (Homo sapiens)
ITGA2B gene [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
ENSEMBL:ENSG00000005961 ITGA2B
Gene Names
ITGA2B, GP2B, ITGAB
Participant Of
input
ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6
RUNX1 and GATA1 bind the promoter of the ITGA2B gene
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
hasComponent
H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2,H3R2me2a-Nucleosome [nucleoplasm]
RUNX1:CBFB:SIN3A,(SIN3B):PRMT6:HDAC1:ITGA2B gene:H3K4me2-Nucleosome [nucleoplasm]
Inferred To
Ghost homologue of ITGA2B gene [nucleoplasm] (Arabidopsis thaliana)
Ghost homologue of ITGA2B gene [nucleoplasm] (Bos taurus)
Ghost homologue of ITGA2B gene [nucleoplasm] (Canis familiaris)
Ghost homologue of ITGA2B gene [nucleoplasm] (Danio rerio)
Ghost homologue of ITGA2B gene [nucleoplasm] (Drosophila melanogaster)
Ghost homologue of ITGA2B gene [nucleoplasm] (Gallus gallus)
Ghost homologue of ITGA2B gene [nucleoplasm] (Mus musculus)
Ghost homologue of ITGA2B gene [nucleoplasm] (Rattus norvegicus)
Ghost homologue of ITGA2B gene [nucleoplasm] (Saccharomyces cerevisiae)
Ghost homologue of ITGA2B gene [nucleoplasm] (Sus scrofa)
Ghost homologue of ITGA2B gene [nucleoplasm] (Taeniopygia guttata)
Ghost homologue of ITGA2B gene [nucleoplasm] (Xenopus tropicalis)
© 2018
Reactome
