Activated PKC phosphorylates SHC1

Stable Identifier
R-HSA-8934446
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Activated PKC phosphorylates SHC1
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Activated protein kinase C alpha (PRKCA), as well as delta (PRKCD) and epsilon (PRKCE), can phosphorylate SHC1 splicing isoforms SHC1-1 (p66Shc) and SHC1-2 (p52Shc) on serine residues S139 and S29, respectively (Habib et al. 1994, Faisal et al. 2002).

Literature References
PubMed ID Title Journal Year
7929214 Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase

Habib, T, Decker, SJ, Herrera, R

J. Biol. Chem. 1994
12052829 Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling

Hess, D, El-Shemerly, M, Faisal, A, Nagamine, Y

J. Biol. Chem. 2002
Participants
Input
Output
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as an event of
Catalyst Activity

protein kinase C activity of Activated PRKCA,(PRKCD,PRKCE) [plasma membrane]

Physical Entity
Activated PRKCA,(PRKCD,PRKCE) [plasma membrane] (Homo sapiens)
Activity
protein kinase C activity (GO:0004697)
Orthologous Events
Activated PKC phosphorylates SHC1 (Canis familiaris)
Activated PKC phosphorylates SHC1 (Danio rerio)
Activated PKC phosphorylates SHC1 (Drosophila melanogaster)
Activated PKC phosphorylates SHC1 (Gallus gallus)
Activated PKC phosphorylates SHC1 (Mus musculus)
Activated PKC phosphorylates SHC1 (Rattus norvegicus)
Activated PKC phosphorylates SHC1 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-08-09)
Reviewed
Ayoub, E  (2016-08-04)
Tremblay, M  (2016-08-04)
Created
Orlic-Milacic, M  (2016-08-09)
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