Activated PKC phosphorylates SHC1

Stable Identifier
R-HSA-8934446
Type
Reaction
Species
Homo sapiens
Compartment
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Activated protein kinase C alpha (PRKCA), as well as delta (PRKCD) and epsilon (PRKCE), can phosphorylate SHC1 splicing isoforms SHC1-1 (p66Shc) and SHC1-2 (p52Shc) on serine residues S139 and S29, respectively (Habib et al. 1994, Faisal et al. 2002).

Literature References
PubMed ID Title Journal Year
7929214 Activators of protein kinase C stimulate association of Shc and the PEST tyrosine phosphatase

Habib, T, Decker, SJ, Herrera, R

J. Biol. Chem. 1994
12052829 Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling

Hess, D, El-Shemerly, M, Faisal, A, Nagamine, Y

J. Biol. Chem. 2002
Participants
Participates
Catalyst Activity

protein kinase C activity of Activated PRKCA,(PRKCD,PRKCE) [plasma membrane]

Orthologous Events
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