ALPI dimer hydrolyses phosphate monoesters

Stable Identifier
Reaction [transition]
Homo sapiens
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Alkaline phosphatases (ALPs) are ubiquitous membrane-bound glycoproteins that catalyse the hydrolysis of phosphate monoesters in alkaline conditions (Sharma et al. 2014). To date, little is known about the physiological function of ALPs in most tissues. In humans, four isozymes exist, named from their tissue localisations. One isozyme, intestinal-type alkaline phosphatase (ALPI, IAP), possesses alkaline phosphatase activity but has no specific physiological substrate defiend for it yet. It may be involved in the hydrolysis of pro-drugs in the intestine (Lowe et al. 1990).

Literature References
PubMed ID Title Journal Year
24966474 Alkaline phosphatase: an overview

Pal, D, Sharma, U, Prasad, R

Indian J Clin Biochem 2014
3458202 Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes

Berger, J, Hua, JC, Hulmes, JD, Udenfriend, S, Pan, YC

Proc. Natl. Acad. Sci. U.S.A. 1986
Catalyst Activity

alkaline phosphatase activity of ALPI:2Ca2+:Mg2+ dimer [plasma membrane]

Orthologous Events
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