Reactome | ALPI dimer hydrolyses phosphate monoesters

ALPI dimer hydrolyses phosphate monoesters

Stable Identifier

R-HSA-8878787

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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ALPI dimer hydrolyses phosphate monoesters

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Alkaline phosphatases (ALPs) are ubiquitous membrane-bound glycoproteins that catalyse the hydrolysis of phosphate monoesters in alkaline conditions (Sharma et al. 2014). To date, little is known about the physiological function of ALPs in most tissues. In humans, four isozymes exist, named from their tissue localisations. One isozyme, intestinal-type alkaline phosphatase (ALPI, IAP), possesses alkaline phosphatase activity but has no specific physiological substrate defiend for it yet. It may be involved in the hydrolysis of pro-drugs in the intestine (Lowe et al. 1990).

Literature References

PubMed ID	Title	Journal	Year
24966474	Alkaline phosphatase: an overview Sharma, U, Pal, D, Prasad, R	Indian J Clin Biochem	2014
3458202	Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes Hua, JC, Berger, J, Pan, YC, Hulmes, JD, Udenfriend, S	Proc. Natl. Acad. Sci. U.S.A.	1986