SSC5D is a secreted member of group B of the SRCR superfamily. Human SSC5D binds surfaces of whole bacteria and is able to discriminate pathogenic strains from non-pathogenic strains (Bessa Pereira et al. 2016). Mouse Ssc5d (S5D-SRCRB) binds bacterial surface polymers (peptidoglycan, lipopolysaccharide), yeast surface polymers (beta-glucan), and glycoproteins (Galectin-1, Galectin-3, Laminin). Human SSC5D may bind similar ligands but this has not yet been demonstrated. Mouse Ssc5d is expressed in the urogenital tract (Miró-Julià et al. 2014).
Bessa Pereira, C,
Martins de Araújo, M,