FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene

Stable Identifier
R-HSA-8877391
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene
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FOXP3 bound to the RUNX1:CBFB complex binds the first intron of the IL2RA (CD25) gene (Ono et al. 2007). It is probable that FOXP3 acts as part of a complex with NFATC2 (Wu et al. 2006).

Literature References
PubMed ID Title Journal Year
17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M, Yaguchi, H, Ohkura, N, Kitabayashi, I, Nagamura, Y, Nomura, T, Miyachi, Y, Tsukada, T, Sakaguchi, S

Nature 2007
16873067 FOXP3 controls regulatory T cell function through cooperation with NFAT

Wu, Y, Borde, M, Heissmeyer, V, Feuerer, M, Lapan, AD, Stroud, JC, Bates, DL, Guo, L, Han, A, Ziegler, SF, Mathis, D, Benoist, C, Chen, L, Rao, A

Cell 2006
Participants
Input
Output
Participant Of
hasEvent
Authored
Orlic-Milacic, M  (2016-09-14)
Reviewed
Ito, Y  (2016-12-20)
Chuang, LS  (2016-12-20)
Created
Orlic-Milacic, M  (2016-06-22)
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