Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CBLL1 [cytosol]
Stable Identifier
R-HSA-8876832
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase Hakai ecNumber6.3.2.-/ecNumber, HAKAI_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Activation of STAT3 by cadherin engagement (Homo sapiens)
SRC activates STAT3 in a quantitative manner, through Cadherin-11 (CDH11), RAC1 and gp130 (IL6ST) (Homo sapiens)
CBLL1 binds p-Y-CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1 ubiquitinates CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Lysosomal degradation of ubiquitinated CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Ubiquitinated CDH1 is endocytosed (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Ubiquitinated CDH1 translocates to lysosomes for degradation (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Function (Homo sapiens)
Degradation of CDH1 (Homo sapiens)
CBLL1 binds p-Y-CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1 ubiquitinates CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Lysosomal degradation of ubiquitinated CDH1 (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Ubiquitinated CDH1 is endocytosed (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Ubiquitinated CDH1 translocates to lysosomes for degradation (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [early endosome membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1:PolyUb-p-2Y-CDH1 [lysosomal membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Listeria monocytogenes entry into host cells (Homo sapiens)
InlA-mediated entry of Listeria monocytogenes into host cells (Homo sapiens)
CBLL1 binds SRC-phosphorylated CDH1 complex (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
CBLL1 ubiqutinates the InlA-bound CDH1 complex (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
InlA:Ub-K,p-Y753,Y754-CDH1:Ub-K,p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
InlA:p-Y753,Y754-CDH1:p-Y-CTNNB1:CBLL1 dimer:Zn2+ [plasma membrane] (Homo sapiens)
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
CBLL1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q75N03 CBLL1
Gene Names
CBLL1, HAKAI, RNF188
Chain
chain:1-491
Reference Genes
BioGPS Gene:79872 CBLL1
COSMIC - genes:CBLL1 CBLL1
CTD Gene:79872 CBLL1
dbSNP Gene:79872 CBLL1
ENSEMBL:ENSG00000105879 CBLL1
HGNC:21225 CBLL1
KEGG:hsa:79872 CBLL1
Monarch:79872 CBLL1
NCBI Gene:79872 CBLL1
OMIM:606872 CBLL1
UCSC:Q75N03 CBLL1
Reference Transcript
RefSeq:NM_024814.4 CBLL1
RefSeq:NM_001284291.2 CBLL1
Other Identifiers
11734716_at
11734717_a_at
17050280
220018_PM_at
220018_at
227187_PM_at
227187_at
3018647
3018653
3018654
3018655
3018656
3018657
3018658
3018659
3018661
3018662
3018663
3018664
3018665
3018666
3018667
3018668
3018669
3018671
3018673
51060_at
75261_at
79872
80561_at
8135458
91917_at
A_23_P146004
A_24_P192338
GE84999
GO:0000151
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006397
GO:0007162
GO:0008270
GO:0016071
GO:0016567
GO:0016607
GO:0016740
GO:0030155
GO:0030335
GO:0036396
GO:0042802
GO:0045807
GO:0046872
GO:0061630
GO:0098609
GO:0140096
HMNXSV003017211
HMNXSV003026340
Hs.44577.0.A1_3p_at
ILMN_1705433
ILMN_2073732
PH_hs_0026366
RNA147199|p0303_imsncRNA622
TC07000696.hg
TC07002520.hg
g13376203_3p_at
Participates
as a component of
CBLL1 dimer:Zn2+ [cytosol] (Homo sapiens)
Inferred To
LOC100002706 [cytosol]
(Danio rerio)
Cbll1 [cytosol]
(Mus musculus)
Cbll1 [cytosol]
(Rattus norvegicus)
CBLL1 [cytosol]
(Bos taurus)
CBLL1 [cytosol]
(Canis familiaris)
CBLL1 [cytosol]
(Gallus gallus)
CBLL1 [cytosol]
(Sus scrofa)
Hakai [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_079090.2
,
NP_001271220.1
ENSEMBL
ENSP00000401277
,
ENSP00000222597
,
ENST00000222597
,
ENSG00000105879
,
ENST00000440859
OpenTargets
ENSG00000105879
GeneCards
CBLL1
HPA
ENSG00000105879-CBLL1
PRO
Q75N03
Pharos - Targets
Q75N03
GlyGen
Q75N03
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98175 RBM10
1
RBM10 [nucleoplasm]
(R-HSA-9770262)
0.556
3
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.483
2
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text