SLC50A1 transports Glc from cytosol to extracellular region

Stable Identifier
Reaction [transition]
Homo sapiens
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In mammals, glucose efflux from the liver is crucial for the maintenance of blood glucose levels (Deng & Yan 2016). Human sugar transporter SWEET1 (SLC50A1) is a ubiquitously expressed transport protein, with highest expression in oviduct, epididymis and intestine. It localises to the Golgi membrane where it may supply glucose to the Golgi for secretion from intestinal and liver cells (Chen et al. 2010).

Literature References
PubMed ID Title Journal Year
26650681 GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

Deng, D, Yan, N

Protein Sci. 2016
21107422 Sugar transporters for intercellular exchange and nutrition of pathogens

Underwood, W, Somerville, SC, White, FF, Kim, JG, Lalonde, S, Guo, WJ, Qu, XQ, Chaudhuri, B, Takanaga, H, Frommer, WB, Chermak, D, Mudgett, MB, Antony, G, Hartung, ML, Hou, BH, Chen, LQ

Nature 2010
Catalyst Activity

sugar transmembrane transporter activity of SLC50A1 [plasma membrane]

Orthologous Events
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