SLC50A1 transports Glc from cytosol to extracellular region

Stable Identifier
R-HSA-8876319
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In mammals, glucose efflux from the liver is crucial for the maintenance of blood glucose levels (Deng & Yan 2016). Human sugar transporter SWEET1 (SLC50A1) is a ubiquitously expressed transport protein, with highest expression in oviduct, epididymis and intestine. It localises to the Golgi membrane where it may supply glucose to the Golgi for secretion from intestinal and liver cells (Chen et al. 2010).

Literature References
PubMed ID Title Journal Year
21107422 Sugar transporters for intercellular exchange and nutrition of pathogens

Chen, LQ, Hou, BH, Lalonde, S, Takanaga, H, Hartung, ML, Qu, XQ, Guo, WJ, Kim, JG, Underwood, W, Chaudhuri, B, Chermak, D, Antony, G, White, FF, Somerville, SC, Mudgett, MB, Frommer, WB

Nature 2010
26650681 GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters

Deng, D, Yan, N

Protein Sci. 2016
Participants
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Catalyst Activity
Title
sugar transmembrane transporter activity of SLC50A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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