SLC26A11 transports SO4(2-) from extracellular region to cytosol

Stable Identifier
R-HSA-8875871
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Lymphocytes migrate from the blood into most secondary lymphoid organs and chronically inflamed tissues through high endothelial venules (HEV). HEV endothelial cells (HEVECs) incorporate large amounts of sulfate into sialomucin-type counter-receptors for the lymphocyte-homing receptor L-selectin. Sulfate uptake into HEVECs is mediated by two functionally-distinct classes of sulfate transporters: Na+-coupled transporters and sulfate/anion exchangers. Sodium-independent sulfate anion transporter SLC26A11 is targeted to the cell membrane and displays Na+-independent sulfate transport activity. SLC26A11 is expressed in kidney, brain and placenta and at lower levels in other tissues (Vincourt et al. 2003).

Literature References
PubMed ID Title Journal Year
12626430 Molecular and functional characterization of SLC26A11, a sodium-independent sulfate transporter from high endothelial venules

Vincourt, JB, Jullien, D, Amalric, F, Girard, JP

FASEB J. 2003
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Participant Of
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Catalyst Activity
Title
sulfate transmembrane transporter activity of SLC26A11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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