Reactome | CBL recruits CIN85:endophilin to ubiquitinated MET

CBL recruits CIN85:endophilin to ubiquitinated MET

Stable Identifier

R-HSA-8875482

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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CBL recruits CIN85:endophilin to ubiquitinated MET

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CBL recruits the complex of SH3KBP1 (CIN85) and endophilin to the activated MET receptor. While CIN85 and endophilin are not involved in CBL tyrosine phosphorylation by activated MET and CBL-mediated MET ubiquitination, they are required for internalization and degradation of the activated MET receptor (Petrelli et al. 2002). CIN85 likely functions as a homotetramer (Watanabe et al. 2000). Endophilin A1 (SH3GL2), A2 (SH3GL1) and A3 (SH3GL3), which function as homodimers, can all be recruited to the activated MET receptor, with SH3GL3 being the most extensively studied (Petrelli et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11894096	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met Gilestro, GF, Migone, N, Lanzardo, S, Giordano, S, Comoglio, PM, Petrelli, A	Nature	2002