ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH

Stable Identifier
R-HSA-8874745
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH
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Mitochondrial 3-ketoacyl-CoA thiolase (ACAA2) is a mitochondrial matrix enzyme involved in fatty acid beta-oxidation, transferring the acyl group from acyl-CoA (acyl-CoA) to acetyl-CoA (Ac-CoA) to form 3-oxyoacyl-CoA (3OA-CoA) and CoA-SH (Abe et al. 1993, Middleton 1973).
Literature References
PubMed ID Title Journal Year
8241273 Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase

Abe, H, Ohtake, A, Yamamoto, S, Satoh, Y, Takayanagi, M, Amaya, Y, Takiguchi, M, Sakuraba, H, Suzuki, Y, Mori, M

Biochim. Biophys. Acta 1993
4721607 The oxoacyl-coenzyme A thiolases of animal tissues

Middleton, B

Biochem. J. 1973
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Output
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as an event of
Catalyst Activity

acetyl-CoA C-acyltransferase activity of ACAA2 tetramer [mitochondrial matrix]

Physical Entity
ACAA2 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
acetyl-CoA C-acyltransferase activity (GO:0003988)
Orthologous Events
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Bos taurus)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Caenorhabditis elegans)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Canis familiaris)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Danio rerio)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Drosophila melanogaster)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Gallus gallus)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Mus musculus)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Rattus norvegicus)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Sus scrofa)
ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH (Xenopus tropicalis)
Authored
Jassal, B  (2016-05-27)
Reviewed
D'Eustachio, P  (2016-07-15)
Created
Jassal, B  (2016-05-27)
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