Reactome | CREB3L3 translocates from the cytosol to the nucleus

CREB3L3 translocates from the cytosol to the nucleus

Stable Identifier

R-HSA-8874202

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

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CREB3L3 translocates from the cytosol to the nucleus

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The N-terminal, cleavage product of CREB3L3 traffics to the nucleus (Omori et al. 2001, Bailey et al. 2007, Llarena et al. 2010) where it can interact with ATF6 and where it is observed to bind the CRE, box B, and ATF6-bindng element, ERSE-I, and ERSE-II in promoters of target genes such as PEPCK.

Literature References

PubMed ID	Title	Journal	Year
19883396	Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6 Llarena, M, Bailey, D, Curtis, H, O'Hare, P	Traffic	2010
11353085	CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression Omori, Y, Imai, J, Watanabe, M, Komatsu, T, Suzuki, Y, Kataoka, K, Watanabe, S, Tanigami, A, Sugano, S	Nucleic Acids Res.	2001
17875199	Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis Bailey, D, Barreca, C, O'Hare, P	Traffic	2007