CREB3L3 translocates from the cytosol to the nucleus

Stable Identifier
Reaction [omitted]
Homo sapiens
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The N-terminal, cleavage product of CREB3L3 traffics to the nucleus (Omori et al. 2001, Bailey et al. 2007, Llarena et al. 2010) where it can interact with ATF6 and where it is observed to bind the CRE, box B, and ATF6-bindng element, ERSE-I, and ERSE-II in promoters of target genes such as PEPCK.

Literature References
PubMed ID Title Journal Year
19883396 Different mechanisms of recognition and ER retention by transmembrane transcription factors CREB-H and ATF6

Llarena, M, Bailey, D, Curtis, H, O'Hare, P

Traffic 2010
11353085 CREB-H: a novel mammalian transcription factor belonging to the CREB/ATF family and functioning via the box-B element with a liver-specific expression

Omori, Y, Imai, J, Watanabe, M, Komatsu, T, Suzuki, Y, Kataoka, K, Watanabe, S, Tanigami, A, Sugano, S

Nucleic Acids Res. 2001
17875199 Trafficking of the bZIP transmembrane transcription factor CREB-H into alternate pathways of ERAD and stress-regulated intramembrane proteolysis

Bailey, D, Barreca, C, O'Hare, P

Traffic 2007
Orthologous Events
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