CREB3L1 translocates from the cytosol to the nucleus

Stable Identifier
R-HSA-8874193
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Cleavage by MBTPS2 releases the N-terminal domain of CREB3L1 into the cytosol and it then traffics to the nucleus (Denard et al. 2011, Rose et al. 2014, Ward et al. 2016, and inferred from mouse homologs).

Literature References
PubMed ID Title Journal Year
26810754 Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers

Ward, AK, Mellor, P, Smith, SE, Kendall, S, Just, NA, Vizeacoumar, FS, Sarker, S, Phillips, Z, Alvi, R, Saxena, A, Vizeacoumar, FJ, Carlsen, SA, Anderson, DH

Breast Cancer Res. 2016
21767813 The membrane-bound transcription factor CREB3L1 is activated in response to virus infection to inhibit proliferation of virus-infected cells

Denard, B, Seemann, J, Chen, Q, Gay, A, Huang, H, Chen, Y, Ye, J

Cell Host Microbe 2011
25625847 OASIS/CREB3L1 is epigenetically silenced in human bladder cancer facilitating tumor cell spreading and migration in vitro

Rose, M, Schubert, C, Dierichs, L, Gaisa, NT, Heer, M, Heidenreich, A, Knuchel, R, Dahl, E

Epigenetics 2014
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