Reactome | SRC phosphorylates PTK2

SRC phosphorylates PTK2

Stable Identifier

R-HSA-8874080

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SRC phosphorylates PTK2 (FAK1) at tyrosine residues Y576 and Y577 in the activation loop of PTK2. Phosphorylation of PTK2 at Y576 and Y577 is required for the full catalytic activity of PTK2 (Calelb et al. 1995, Lietha et al. 2007) and is facilitated by MET-mediated phosphorylation of PTK2 at Y194. MET is able to phosphorylate PTK2 at Y576 and Y577 in vitro, in the absence of SRC (Chen et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
17574028	Structural basis for the autoinhibition of focal adhesion kinase Lietha, D, Cai, X, Ceccarelli, DF, Li, Y, Schaller, MD, Eck, MJ	Cell	2007
20802513	Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition Chen, TH, Chan, PC, Chen, CL, Chen, HC	Oncogene	2011