SRC phosphorylates PTK2

Stable Identifier
R-HSA-8874080
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SRC phosphorylates PTK2 (FAK1) at tyrosine residues Y576 and Y577 in the activation loop of PTK2. Phosphorylation of PTK2 at Y576 and Y577 is required for the full catalytic activity of PTK2 (Calelb et al. 1995, Lietha et al. 2007) and is facilitated by MET-mediated phosphorylation of PTK2 at Y194. MET is able to phosphorylate PTK2 at Y576 and Y577 in vitro, in the absence of SRC (Chen et al. 2011).

Literature References
PubMed ID Title Journal Year
20802513 Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

Chen, TH, Chan, PC, Chen, CL, Chen, HC

Oncogene 2011
17574028 Structural basis for the autoinhibition of focal adhesion kinase

Lietha, D, Cai, X, Ceccarelli, DF, Li, Y, Schaller, MD, Eck, MJ

Cell 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of HGF:p-4Y-MET dimer:p-Y194,Y397-PTK2:MyrG-p-Y419-SRC [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created