Reactome | STARD5 binds DCA, LCA

STARD5 binds DCA, LCA

Stable Identifier

R-HSA-8873850

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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StAR-related lipid transfer protein 5 (STARD5) is highly expressed in at least three cell types targeted by bile acids: liver macrophage Kupffer cells, peripheral macrophages and kidney proximal tubule cells. Unlike the other members of the STARD4 subfamily of the START-containing proteins (members 4 and 6), STARD5 possesses low or no affinity for cholesterol but instead, specifically binds primary and secondary bile acids. STARD5's affinity for the secondary bile acids deoxycholic acid (DCA) and lithocholic acid (LCA), which lack the alpha-OH in C7, is greater than that of the primary bile acids cholic acid (CA) and chenodeoxycholic acid (CDCA) (Letourneau et al. 2012, Letourneau et al. 2013). The physiological roles played by STARD5 remain to be elucidated but it could act as a bile acid transporter or sensor.

Literature References

PubMed ID	Title	Journal	Year
23337244	STARD5 specific ligand binding: comparison with STARD1 and STARD4 subfamilies Lefebvre, A, LeHoux, JG, Létourneau, D, Lavigne, P	Mol. Cell. Endocrinol.	2013
23018617	StAR-related lipid transfer domain protein 5 binds primary bile acids Lorin, A, Lefebvre, A, LeHoux, JG, Najmanovich, R, Gaudreault, F, Létourneau, D, Lavigne, P, Frappier, V	J. Lipid Res.	2012