PCTP binds PC

Stable Identifier
R-HSA-8873794
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Phosphatidylcholine transfer protein (PCTP aka STARD2) is a member of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain superfamily, a functionally diverse group of proteins that share a unique structural motif for binding lipids (the START domain). PCTP is widely expressed with highest expression levels in oxidative tissues, including liver, heart, muscle, kidney and brown fat but very little expression in white adipose tissue. PCTP exclusively binds phosphatidylcholine (PC) in the cytosol of cells and may mediate PC exchange at cellular membranes (Roderick et al. 2002). Recent mouse studies reveals a key regulatory role for PCTP in lipid and glucose metabolism. PCTP appears to limit access of fatty acids to mitochondria by binding to (Ersoy et al. 2013) and stimulating the activity of acyl-coenzyme A thioesterase 13 (ACOT13, aka Acyl-CoA thioesterase 13, THEM2), an enzyme that catalyses the hydrolysis of acyl-CoAs to their free fatty acids (Kawano et al. 2014). Ultimately, insulin signaling is downregulated (Kang et al. 2010).

Literature References
PubMed ID Title Journal Year
12055623 Structure of human phosphatidylcholine transfer protein in complex with its ligand

Roderick, SL, Chan, WW, Agate, DS, Olsen, LR, Vetting, MW, Rajashankar, KR, Cohen, DE

Nat. Struct. Biol. 2002
23901139 Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling

Ersoy, BA, Tarun, A, D'Aquino, K, Hancer, NJ, Ukomadu, C, White, MF, Michel, T, Manning, BD, Cohen, DE

Sci Signal 2013
20338778 PC-TP/StARD2: Of membranes and metabolism

Kang, HW, Wei, J, Cohen, DE

Trends Endocrinol. Metab. 2010
24732803 Thioesterase superfamily member 2 (Them2) and phosphatidylcholine transfer protein (PC-TP) interact to promote fatty acid oxidation and control glucose utilization

Kawano, Y, Ersoy, BA, Li, Y, Nishiumi, S, Yoshida, M, Cohen, DE

Mol. Cell. Biol. 2014
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