Phosphorylated FOXO3 translocates to the nucleus

Stable Identifier
R-HSA-8870628
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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CDK5-mediated phosphorylation of the transcription factor FOXO3 promotes translocation of FOXO3 from the cytosol to the nucleus (Shi et al. 2016).

Literature References
PubMed ID Title Journal Year
26962010 Cdk5-FOXO3a axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Shi, C, Viccaro, K, Lee, HG, Shah, K

J. Cell. Sci. 2016
Participants
Participant Of
Disease
Name Identifier Synonyms
Alzheimer's disease 10652 AD, Alzheimers dementia, Alzheimer disease
Authored
Created
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