TFAP2A in complex with DEK binds the APOE gene promoter

Stable Identifier
R-HSA-8869575
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TFAP2A in complex with DEK binds the APOE gene promoter
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DEK is recruited to the APOE gene promoter via its interaction with the TFAP2A (AP-2 alpha) homodimer. In the presence of DEK, TFAP2A associates with the APOE promoter more tightly (Campillos et al. 2003). Binding of TFAP2A to the APOE gene promoter may be stimulated by PKA-mediated phosphorylation of TFAP2A (Garcia et al. 1999).
Literature References
PubMed ID Title Journal Year
12595566 Transcriptional activation by AP-2alpha is modulated by the oncogene DEK

Campillos, M, Valdivieso, F, Vázquez, J, García, MA

Nucleic Acids Res. 2003
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Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Dawid, IB  (2016-05-04)
Created
Orlic-Milacic, M  (2016-05-05)
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