The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer

Stable Identifier
R-HSA-8869566
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer
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In the course of retinoic acid-induced cell differentiation, formation of the complex between NPM1 (nucleophosmin) and TFAP2A (AP-2 alpha) homodimer, bound to the AP-2 alpha response element in the promoter of the MYBL2 (b-Myb) gene, represses transcription of the transcription factor MYBL2. Transcriptional repression probably involves NPM1-mediated recruitment of histone deacetylases HDAC1 and HDAC2 to the MYBL2 gene promoter (Liu et al. 2007). MYBL2 is involved in promotion of cellular proliferation (Saville and Watson 1998).
Literature References
PubMed ID Title Journal Year
17318229 Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation

Yung, BY, Chuang, CP, Chen, KD, Tseng, KH, Tan, BC, Yeh, CW, Liu, H, Lee, SC

EMBO Rep. 2007
Participants
Input
Output
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as an event of
This event is regulated
Negatively by
Regulator
NPM1:TFAP2A homodimer:MYBL2 gene [nucleoplasm] (Homo sapiens)
Active Unit
NPM1:TFAP2A homodimer [nucleoplasm]
Authored
Orlic-Milacic, M  (2016-03-14)
Reviewed
Zarelli, VE  (2016-05-04)
Dawid, IB  (2016-05-04)
Created
Orlic-Milacic, M  (2016-05-05)
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