Reactome | TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6

TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6

Stable Identifier

R-HSA-8869506

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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TNFAIP3 in OTUD7B:TNFAIP3:ZRANB1 deubiquitinates K63polyUb-TRAF6

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TNFAIP3 can remove K63-linked ubiquitin from TRAF6, which terminates signalling by Toll-like receptors (Boone et al. 2004). TNFAIP3 is essential for the termination of NFkappaB activation in response to multiple stimuli such as IL-1beta, TNF, IL-6, CD40 and lipopolysaccharide (LPS). Removal of K63-linked ubiquitin is not necessarily followed by K48-ubiquitination that would lead to degradation (Vereecke et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
15334086	The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses Boone, DL, Turer, EE, Lee, EG, Ahmad, RC, Wheeler, MT, Tsui, C, Hurley, P, Chien, M, Chai, S, Hitotsumatsu, O, McNally, E, Pickart, C, Ma, A	Nat. Immunol.	2004