OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

Stable Identifier
R-HSA-8868402
Type
Reaction
Species
Homo sapiens
Compartment
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Oxysterol-binding protein 1 (OSBP) is involved in lipid countertransport between the Golgi and the ER membranes. It specifically exchanges sterols such as 25-hydroxycholesterol (25OH-CHOL) with phosphatidylinositol 4-phosphate (PI4P), delivering it to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatases in the ER. The PH-FFAT region of OSBP is necessary for membrane tethering, which then directs forward sterol and backward PI4P transport by the ORD domain of OSBP (Mesmin et al. 2013).

Literature References
PubMed ID Title Journal Year
24209621 A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP

Moser von Filseck, J, Lacas-Gervais, S, Bigay, J, Drin, G, Mesmin, B, Antonny, B

Cell 2013
Participants
Participates
Catalyst Activity

sterol transporter activity of OSBP [cytosol]

Orthologous Events
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