OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

Stable Identifier
R-HSA-8868402
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Oxysterol-binding protein 1 (OSBP) is involved in lipid countertransport between the Golgi and the ER membranes. It specifically exchanges sterols such as 25-hydroxycholesterol (25OH-CHOL) with phosphatidylinositol 4-phosphate (PI4P), delivering it to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatases in the ER. The PH-FFAT region of OSBP is necessary for membrane tethering, which then directs forward sterol and backward PI4P transport by the ORD domain of OSBP (Mesmin et al. 2013).

Literature References
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
sterol transporter activity of OSBP [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed