Reactome | OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

Stable Identifier

R-HSA-8868402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane, Golgi membrane

ReviewStatus

5/5

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OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane

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Oxysterol-binding protein 1 (OSBP) is involved in lipid countertransport between the Golgi and the ER membranes. It specifically exchanges sterols such as 25-hydroxycholesterol (25OH-CHOL) with phosphatidylinositol 4-phosphate (PI4P), delivering it to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatases in the ER. The PH-FFAT region of OSBP is necessary for membrane tethering, which then directs forward sterol and backward PI4P transport by the ORD domain of OSBP (Mesmin et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
24209621	A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP Mesmin, B, Bigay, J, Moser von Filseck, J, Lacas-Gervais, S, Drin, G, Antonny, B	Cell	2013