Glycophorins bind plasmodium falciparum Ags

Stable Identifier
Reaction [binding]
Homo sapiens
Related Species
Plasmodium falciparum
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Red blood cell (RBC) glycophorins are integral membrane proteins that are rich in sialic acids. They carry blood group antigenic determinants and serve as ligands for viruses, bacteria, and parasites. They are used as markers to study normal and pathological differentiation of erythroid tissue. RBC glycophorins include glycophorins A (GPYA) to E and are divided into two groups. GPYA and GPYB carry MN and Ss blood group antigens and may act as receptors for Plasmodium falciparum (Cartron & Rahuel 1992). GPYA and GPYB are recognized by P. falciparum erythrocyte-binding antigen 175 (EBA-175) (Wanaguru et al. 2013) and erythrocyte-binding ligand 1 (EBL-1) (Mayer et al. 2009), respectively. GLYC codes for the Gerbich (Ge) blood group antigens and is a receptor for P. falciparum invasion, recognizing EBA-140 on the surface of merozoites (Maier et al. 2003).

Literature References
PubMed ID Title Journal Year
19279206 Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1

Cofie, J, Miller, LH, Mendoza, LH, Mayer, DC, Kabát, J, Tracy, E, Jiang, L, Hartl, DL

Proc. Natl. Acad. Sci. U.S.A. 2009
12469115 Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations

Cowman, AF, Zimmerman, PA, Maier, AG, Kazura, JW, Duraisingh, MT, Reeder, JC, Patel, SS

Nat. Med. 2003
1591491 Human erythrocyte glycophorins: protein and gene structure analyses

Rahuel, C, Cartron, JP

Transfus Med Rev 1992
24043627 Biochemical analysis of the Plasmodium falciparum erythrocyte-binding antigen-175 (EBA175)-glycophorin-A interaction: implications for vaccine design

Crosnier, C, Wanaguru, M, Johnson, S, Wright, GJ, Rayner, JC

J. Biol. Chem. 2013
Name Identifier Synonyms
malaria DOID:12365 induced malaria
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