BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Human Bromodomain and WD repeat-containing protein 1 (BRWD1) binds to histone H3 acetylated at lysine residues K9, K14, K18 and K79 and phosphorylated at serine residue S10 and threonine residue T11 in various combinations in vitro (Filippakopoulos et al. 2012). In mouse, it was confirmed that BRWD1 interacts with histone H3 acetylated at lysine residues K9 and K14, and phosphorylated at serine residue S10 (Mandal et al. 2015). Please note that the listed amino acid residues in mature histone H3 match nascent histone H3 residues K10, K15, K19, K80, S11 and T12, respectively. Amino acid positions in Reactome annotations of modified residues and Reactome systematic names correspond to positions in the nascent protein UniProt sequence.
Literature References
PubMed ID Title Journal Year
22464331 Histone recognition and large-scale structural analysis of the human bromodomain family

Pawson, T, Knapp, S, Barsyte-Lovejoy, D, Filippakopoulos, P, Gingras, AC, Arrowsmith, CH, Picaud, S, Lambert, JP, Volkmer, R, Felletar, I, Mangos, M, Müller, S, Keates, T

Cell 2012
26301565 Histone reader BRWD1 targets and restricts recombination to the Igk locus

Schatz, DG, Hamel, KM, Tuteja, JH, Mandal, M, Bunker, JJ, Bahroos, N, Eppig, JJ, Tanaka, A, Maienschein-Cline, M, Clark, MR, Teng, G

Nat. Immunol. 2015
Orthologous Events
Cite Us!