Reactome | BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3

BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3

Stable Identifier

R-HSA-8865613

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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BRWD1 binds AcK(9,14,18,79)-p(S10,T11)-histone H3

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Human Bromodomain and WD repeat-containing protein 1 (BRWD1) binds to histone H3 acetylated at lysine residues K9, K14, K18 and K79 and phosphorylated at serine residue S10 and threonine residue T11 in various combinations in vitro (Filippakopoulos et al. 2012). In mouse, it was confirmed that BRWD1 interacts with histone H3 acetylated at lysine residues K9 and K14, and phosphorylated at serine residue S10 (Mandal et al. 2015). Please note that the listed amino acid residues in mature histone H3 match nascent histone H3 residues K10, K15, K19, K80, S11 and T12, respectively. Amino acid positions in Reactome annotations of modified residues and Reactome systematic names correspond to positions in the nascent protein UniProt sequence.

Literature References

PubMed ID	Title	Journal	Year
22464331	Histone recognition and large-scale structural analysis of the human bromodomain family Filippakopoulos, P, Picaud, S, Mangos, M, Keates, T, Lambert, JP, Barsyte-Lovejoy, D, Felletar, I, Volkmer, R, Müller, S, Pawson, T, Gingras, AC, Arrowsmith, CH, Knapp, S	Cell	2012
26301565	Histone reader BRWD1 targets and restricts recombination to the Igk locus Mandal, M, Hamel, KM, Maienschein-Cline, M, Tanaka, A, Teng, G, Tuteja, JH, Bunker, JJ, Bahroos, N, Eppig, JJ, Schatz, DG, Clark, MR	Nat. Immunol.	2015