The heterodimerization domain of CBFB binds to the Runt domain of RUNX1 (AML1) to form a RUNX1:CBFB heterodimer (Warren et al. 2000, Lukasik et al. 2002). Formation of the RUNX1:CBFB heterodimer was first demonstrated in Drosophila (Ogawa et al. 1993). While RUNX1 is the DNA binding subunit, the presence of CBFB is necessary for the transcriptional activity of the RUNX1:CBFB complex, based on knockout mouse studies (Wang et al. 1996).The RUNX1:CBFB transcription complex is essential for hematopoiesis (Warren et al. 2000).
Both CBFB and RUNX1 are subject to frequent mutations in leukemia (Ustun and Marcucci 2015).
Ogawa, E, Inuzuka, M, Maruyama, M, Satake, M, Naito-Fujimoto, M, Ito, Y, Shigesada, K
Warren, AJ, Bravo, J, Williams, RL, Rabbitts, TH
Lukasik, SM, Zhang, L, Corpora, T, Tomanicek, S, Li, Y, Kundu, M, Hartman, K, Liu, PP, Laue, TM, Biltonen, RL, Speck, NA, Bushweller, JH
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