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Ub-C88-UBE2B [nucleoplasm]
Stable Identifier
R-HSA-8864168
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ubiquitin-conjugating enzyme E2 B ecNumber evidence="11"2.3.2.23/ecNumber, UBE2B_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein ubiquitination (Homo sapiens)
E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
RNF20:RNF40 binds PAF complex, Ubiquitin:UBE2A,B (Ubiquitin:RAD6), WAC and Histone H2B (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
Ub:UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2B [nucleoplasm] (Homo sapiens)
Ub:UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2B [nucleoplasm] (Homo sapiens)
RNF20:RNF40 monoubiquitinates Histone H2B (Homo sapiens)
PAF1c:WAC:RNF20:RNF40:Ub:UBE2A,B:HIST1H2B [nucleoplasm] (Homo sapiens)
Ub:UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2A,B [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2B [nucleoplasm] (Homo sapiens)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2B [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63146 UBE2B
Gene Names
UBE2B, RAD6B, UBCH1
Chain
chain:1-152
Reference Genes
BioGPS Gene:7320 UBE2B
COSMIC (genes):UBE2B UBE2B
CTD Gene:7320 UBE2B
dbSNP Gene:7320 UBE2B
ENSEMBL:ENSG00000119048 UBE2B
HGNC:12473 UBE2B
KEGG:hsa:7320 UBE2B
Monarch:7320 UBE2B
NCBI Gene:7320 UBE2B
OMIM:179095 UBE2B
UCSC:P63146 UBE2B
Reference Transcript
RefSeq:NM_003337.3 UBE2B
Other Identifiers
11742880_a_at
11742881_s_at
11745743_x_at
1231_at
16989243
202333_PM_s_at
202333_s_at
202334_3p_s_at
202334_PM_s_at
202334_s_at
202335_PM_s_at
202335_s_at
211763_PM_s_at
211763_s_at
2829276
2829277
2829278
2829279
2829281
2829282
2829283
2829284
2829288
2829294
2829295
2829298
2829299
2829300
2829301
2829302
7320
74932_at
8108066
86213_at
89867_at
89960_at
A_14_P101415
A_23_P167595
A_24_P200583
GE58070
GO:0000209
GO:0000785
GO:0001701
GO:0001741
GO:0003824
GO:0004842
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005886
GO:0006281
GO:0006301
GO:0006325
GO:0006511
GO:0006915
GO:0006974
GO:0007010
GO:0007283
GO:0007288
GO:0009410
GO:0009411
GO:0010845
GO:0012501
GO:0016567
GO:0016740
GO:0019787
GO:0022414
GO:0030163
GO:0031625
GO:0032446
GO:0033503
GO:0035234
GO:0043066
GO:0043161
GO:0043226
GO:0043951
GO:0045141
GO:0048856
GO:0050821
GO:0051026
GO:0051093
GO:0051865
GO:0061631
GO:0070193
GO:0070534
GO:0070936
GO:0070979
GO:0090263
GO:0140096
GO:1901874
GO:2000242
HMNXSV003047132
Hs.165681.0.A1_3p_at
Hs.811.0.A1_3p_s_at
Hs.811.0.A2_3p_a_at
ILMN_1663099
M74525_at
PH_hs_0024378
TC05000659.hg
g13543659_3p_s_at
Participates
as a member of
Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
Ub-C88-UBE2A,B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
UBE2B [nucleoplasm]
UBE2B [cytosol]
Inferred To
Ub-C88-UBE2A [nucleoplasm]
(Plasmodium falciparum)
ubc2 [nucleoplasm]
(Dictyostelium discoideum)
ube2b [nucleoplasm]
(Danio rerio)
ube2b [nucleoplasm]
(Xenopus tropicalis)
UBE2B [nucleoplasm]
(Bos taurus)
UBE2B [nucleoplasm]
(Canis familiaris)
UBE2B [nucleoplasm]
(Sus scrofa)
rhp6 [nucleoplasm]
(Schizosaccharomyces pombe)
Ube2b [nucleoplasm]
(Mus musculus)
Ube2b [nucleoplasm]
(Rattus norvegicus)
RAD6 [nucleoplasm]
(Saccharomyces cerevisiae)
ubc-1 [nucleoplasm]
(Caenorhabditis elegans)
Ub-C88-UBE2B [nucleoplasm]
(Gallus gallus)
Ub-C88-UBE2B [nucleoplasm]
(Plasmodium falciparum)
Ubc6 [nucleoplasm]
(Drosophila melanogaster)
Homologues of Ub-C88-UBE2B [nucleoplasm]
(Plasmodium falciparum)
Modified Residues
Name
S-(glycyl)-L-cysteine (Cys-Gly) at 88
Coordinate
88
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_003328.1
ENSEMBL
ENST00000265339
,
ENSP00000265339
OpenTargets
ENSG00000119048
IntEnz
2.3.2.23
HPA
ENSG00000119048-UBE2B
PRO
P63146
Pharos - Targets
P63146
HMDB Protein
HMDBP00595
PDB
2YBF
,
1JAS
,
2YB6
,
2Y4W
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