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SPPL2A [plasma membrane]
Stable Identifier
R-HSA-8863106
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
fullName evidence="13 15"Signal peptide peptidase-like 2A, SPP2A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
SPPL2a/b cleaves TNF(1-76) (Homo sapiens)
SPPL2A,SPPL2B [plasma membrane] (Homo sapiens)
SPPL2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TCT8 SPPL2A
Gene Names
SPPL2A, IMP3, PSL2, PSEC0147
Chain
signal peptide:1-25, chain:26-520
Reference Genes
BioGPS Gene:84888 SPPL2A
COSMIC (genes):SPPL2A SPPL2A
CTD Gene:84888 SPPL2A
dbSNP Gene:84888 SPPL2A
ENSEMBL:ENSG00000138600 SPPL2A
ENSEMBL:ENSG00000138600.11 SPPL2A
HGNC:30227 SPPL2A
KEGG Gene (Homo sapiens):84888 SPPL2A
Monarch:84888 SPPL2A
NCBI Gene:84888 SPPL2A
OMIM:608238 SPPL2A
UCSC:Q8TCT8 SPPL2A
Reference Transcript
RefSeq:NM_032802.3 SPPL2A
Other Identifiers
11721125_at
16809187
226353_PM_at
226353_at
227682_PM_at
227682_at
228478_PM_at
228478_at
3623481
3623483
3623487
3623488
3623864
3623866
3623867
3623868
3623869
3623870
3623871
3623872
3623878
3623880
3623882
3623886
3623892
3623893
3623897
3623898
3623900
3623903
3623906
3623907
3623908
3623909
3623910
3623911
44149_at
48405_at
60050_at
63296_at
7988753
84888
A_23_P77073
A_24_P646168
A_32_P50655
GE87776
GE88610
GO:0002376
GO:0003824
GO:0004190
GO:0005515
GO:0005576
GO:0005615
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005783
GO:0005886
GO:0006508
GO:0006509
GO:0008233
GO:0010803
GO:0016020
GO:0016787
GO:0023052
GO:0030660
GO:0031293
GO:0031410
GO:0031902
GO:0033619
GO:0042500
GO:0042803
GO:0043226
GO:0043231
GO:0050776
GO:0070062
GO:0098553
GO:0098554
GO:0140096
HMNXSV003027538
HMNXSV003045881
Hs.167619.0.S1_3p_at
Hs.28980.0.A1_3p_at
Hs.99216.0.A1_3p_at
ILMN_1734229
PH_hs_0002526
TC15001358.hg
Participates
as a member of
SPPL2A,SPPL2B [plasma membrane] (Homo sapiens)
Inferred To
sppl2a [plasma membrane]
(Xenopus tropicalis)
Sppl2a [plasma membrane]
(Mus musculus)
Sppl2a [plasma membrane]
(Rattus norvegicus)
SPPL2A [plasma membrane]
(Bos taurus)
SPPL2A [plasma membrane]
(Canis familiaris)
SPPL2A [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_116191.2
OpenTargets
ENSG00000138600
GeneCards
Q8TCT8
HPA
ENSG00000138600-SPPL2A
Ensembl
ENST00000261854
,
ENSP00000261854
,
ENSG00000138600
PRO
Q8TCT8
Pharos - Targets
Q8TCT8
Orphanet
24943
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
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