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SPPL2A [plasma membrane]
Stable Identifier
R-HSA-8863106
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
fullName evidence="13 15"Signal peptide peptidase-like 2A, SPP2A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
SPPL2a/b cleaves TNF(1-76) (Homo sapiens)
SPPL2A,SPPL2B [plasma membrane] (Homo sapiens)
SPPL2A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TCT8 SPPL2A
Gene Names
SPPL2A, IMP3, PSL2, PSEC0147
Chain
signal peptide:1-25, chain:26-520
Reference Genes
BioGPS Gene:84888 SPPL2A
COSMIC (genes):IMP3 IMP3
COSMIC (genes):SPPL2A SPPL2A
CTD Gene:84888 SPPL2A
dbSNP Gene:84888 SPPL2A
ENSEMBL:ENSG00000138600 SPPL2A
HGNC:30227 SPPL2A
KEGG:hsa:84888 SPPL2A
Monarch:84888 SPPL2A
NCBI Gene:84888 SPPL2A
OMIM:608238 SPPL2A
UCSC:Q8TCT8 SPPL2A
Reference Transcript
RefSeq:NM_032802.3 SPPL2A
Other Identifiers
11721125_at
16809187
226353_PM_at
226353_at
227682_PM_at
227682_at
228478_PM_at
228478_at
3623481
3623483
3623487
3623488
3623864
3623866
3623867
3623868
3623869
3623870
3623871
3623872
3623877
3623878
3623879
3623880
3623882
3623883
3623884
3623885
3623886
3623887
3623892
3623893
3623894
3623895
3623896
3623897
3623898
3623900
3623903
3623904
3623905
3623906
3623907
3623908
3623909
3623910
3623911
3623912
3623913
44149_at
48405_at
60050_at
63296_at
7988753
84888
A_23_P77073
A_24_P646168
A_32_P50655
GE87776
GE88610
GO:0003824
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005770
GO:0005773
GO:0005886
GO:0006508
GO:0006509
GO:0008233
GO:0010008
GO:0010803
GO:0016020
GO:0016787
GO:0030660
GO:0031293
GO:0031410
GO:0031902
GO:0033619
GO:0042500
GO:0042803
GO:0043226
GO:0043231
GO:0050776
GO:0070062
GO:0098553
GO:0098554
GO:0140096
HMNXSV003027538
HMNXSV003045881
HMNXSV003054596
Hs.167619.0.S1_3p_at
Hs.28980.0.A1_3p_at
Hs.99216.0.A1_3p_at
ILMN_1734229
PH_hs_0002526
TC15001358.hg
Participates
as a member of
SPPL2A,SPPL2B [plasma membrane] (Homo sapiens)
Inferred To
sppl2a [plasma membrane]
(Xenopus tropicalis)
Sppl2a [plasma membrane]
(Mus musculus)
Sppl2a [plasma membrane]
(Rattus norvegicus)
SPPL2A [plasma membrane]
(Bos taurus)
SPPL2A [plasma membrane]
(Canis familiaris)
SPPL2A [plasma membrane]
(Sus scrofa)
Cross References
ENSEMBL
ENSG00000138600
,
ENST00000261854
,
ENSP00000261854
OpenTargets
ENSG00000138600
GeneCards
SPPL2A
HPA
ENSG00000138600-SPPL2A
PRO
Q8TCT8
Pharos - Targets
Q8TCT8
GlyGen
Q8TCT8
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
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