SL (surrogate light chain) binds IgH to form pre-BCR

Stable Identifier
R-HSA-8858498
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SL (surrogate light chain) binds IgH to form pre-BCR
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The pre-BCR is a heterodimer composed of an immunoglobulin (Ig) heavy chain molecule (IgH) covalently associated with an immunoglobulin light chain-like molecule called the surrogate light chain (SL). The SL consists of two non-covalently associated proteins called lamda-5 (CD179a) and VPREB (CD179b) (Melchers 1993). Pre-BCR signalling promotes the generation of a large pool of precursor cells that can undergo light-chain gene rearrangement (Rickert 2013).
Literature References
PubMed ID Title Journal Year
8166770 The surrogate light chain in B-cell development

Melchers, F, Karasuyama, H, Haasner, D, Bauer, S, Kudo, A, Sakaguchi, N, Jameson, B, Rolink, A

Immunol. Today 1993
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Authored
Garapati, P V  (2016-02-19)
Reviewed
Meldal, BH  (2016-09-14)
Created
Garapati, P V  (2016-02-19)
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