Reactome | SL (surrogate light chain) binds IgH to form pre-BCR

SL (surrogate light chain) binds IgH to form pre-BCR

Stable Identifier

R-HSA-8858498

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SL (surrogate light chain) binds IgH to form pre-BCR

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The pre-BCR is a heterodimer composed of an immunoglobulin (Ig) heavy chain molecule (IgH) covalently associated with an immunoglobulin light chain-like molecule called the surrogate light chain (SL). The SL consists of two non-covalently associated proteins called lamda-5 (CD179a) and VPREB (CD179b) (Melchers 1993). Pre-BCR signalling promotes the generation of a large pool of precursor cells that can undergo light-chain gene rearrangement (Rickert 2013).

Literature References

PubMed ID	Title	Journal	Year
8166770	The surrogate light chain in B-cell development Jameson, B, Sakaguchi, N, Karasuyama, H, Melchers, F, Bauer, S, Haasner, D, Rolink, A, Kudo, A	Immunol. Today	1993