Reactome | ANGPTL8 binds ANGPTL3

ANGPTL8 binds ANGPTL3

Stable Identifier

R-HSA-8856525

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Angiopoietin-like proteins (ANGPTLs) play major roles in the trafficking and metabolism of lipids. Angiopoietin-like protein 8 (ANGPTL8, aka betatrophin, lipasin) can regulate ANGPTL3 by binding to and promoting cleavage of it, thereby further activating ANGPTL3 (a protein that plays a critical role in the regulation of triglyceride and cholesterol plasma levels, via reversible inhibition of lipoprotein lipase activity) (Ren et al. 2012, Quagliarini et al. 2012, Li & Teng 2014). The exact mechanism of action of ANGPTL8 on ANGPTL3 is poorly understood.

Literature References

PubMed ID	Title	Journal	Year
22569073	Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism Ren, G, Kim, JY, Smas, CM	Am. J. Physiol. Endocrinol. Metab.	2012
24960069	Angiopoietin-like proteins 3, 4 and 8: regulating lipid metabolism and providing new hope for metabolic syndrome Li, Y, Teng, C	J Drug Target	2014
23150577	Atypical angiopoietin-like protein that regulates ANGPTL3 Quagliarini, F, Wang, Y, Kozlitina, J, Grishin, NV, Hyde, R, Boerwinkle, E, Valenzuela, DM, Murphy, AJ, Cohen, JC, Hobbs, HH	Proc. Natl. Acad. Sci. U.S.A.	2012