Reactome | PTPN22 dissociates from CSK

PTPN22 dissociates from CSK

Stable Identifier

R-HSA-8855375

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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In unstimulated T-lymphocytes, protein tyrosine phosphatase PTPN22 (LYP, PEP) is associated with CSK, which inhibits the catalytic activity of PTPN22. In response to TCR-stimulation, the complex of CSK and PTPN22 dissociates through an unknown mechanism, which allows PTPN22 to be recruited to lipid rafts. The PTPN22 variant PTPN22 R620W, the result of a SNP associated with autoimmune diseases, does not bind to CSK and is constitutively active (Vang et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22426112	LYP inhibits T-cell activation when dissociated from CSK Liu, WH, Mustelin, T, Tautz, L, Tremblay, ML, Page, R, Tasken, K, Musumeci, L, Vang, T, Wu, S, Vasile, S, Lie, BA, Yang, L, Landskron, J, Francis, D, Rahmouni, S, Rickert, RC, Dahl, R, Delacroix, L	Nat. Chem. Biol.	2012